EnrichNet

EnrichNet is a network-based enrichment analysis method to identify functional associations between user-defined gene or protein sets and cellular pathways. The datasets are mapped onto a protein interaction network (or other user-defined molecular network) and their pairwise associations are assessed by computing a graph-based statistic, i.e. distances between the network nodes are mapped against a background model. In contrast to the classical overlap-based enrichment analysis, associations can also be identified for non-overlapping gene/protein sets and the user can investigate them in detail by visualizing corresponding sub-graphs.

Publications

• DOI BibTeX
  E. Glaab, A. Baudot, N. Krasnogor, R. Schneider, A. Valencia
  EnrichNet: network-based gene set enrichment analysis
  in Bioinformatics, 28(18):i451-i457, September 2012

  @ARTICLE{Glaab2012a,
    title = {EnrichNet: network-based gene set enrichment analysis},
    author = {Glaab, E. and Baudot, A. and Krasnogor, N. and Schneider, R. and Valencia, A.},
    year = 2012,
    doi = {10.1093/bioinformatics/bts389},
    month = sep,
    journal = {Bioinformatics},
    volume = {28},
    number = {18},
    pages = {i451--i457}
  }