A library of quantitative markers of seizure severity

Understanding fluctuations in seizure severity within individuals is important for determining treatment outcomes and responses to therapy, as well as assessing novel treatments for epilepsy. Current methods for grading seizure severity rely on qualitative interpretations from patients and clinicians. Quantitative measures of seizure severity would complement existing approaches to electroencephalographic (EEG) monitoring, outcome monitoring, and seizure prediction. Therefore, we developed a library of quantitative EEG markers that assess the spread and intensity of abnormal electrical activity during and after seizures.

In this talk, I will discuss the results of analysis of intracranial EEG recordings of over a thousand of seizures. I will also demonstrate the the feasibility of using quantitative iEEG markers to distinguish between seizure types and severity. Finally, I will discuss the idea of a seizure severity library collaboratively expanded by the epilepsy research community.