From switchable DNA nanodevices to light-up bio-orthogonal RNA nanoribbon

In recent years, self-assembled nucleic acid origami nanostructures have been synthesized for applications in nanofabrication, computation, drug delivery, and biosensing. Current research focuses on the synthesis in living cells that would allow control over their processes.

In this talk, I will present switchable DNA origamis for biosensing and targeted delivery, discuss a protocol for multi-strand scaffolded RNA origami assembly, and demonstrate the possibility to encode functional RNA assemblies to be expressed and monitored in vivo through a protein-free split aptamer.