Fluctuations in EEG band power at subject-specific timescales over minutes to days explain changes in seizure evolutions

Epilepsy is a common neurological condition characterised by recurrent, unprovoked seizures. It affects approximately 1% of the world's population and a third of patients experience refractory epilepsy, where seizures are not adequately controlled despite medication. Importantly, epilepsy is recognised as a dynamic disease, where seizure characteristics themselves change over time. This variability can be captured using intracranial electroencephalogram (EEG) and quantified by the characteristic electrographic spatio-temporal seizure evolutions that exist within individual patients. It has been suggested that this variability follows circadian (or longer) timescale modulations.

In this talk, I will describe my work on using EEG features to capture signatures of the seizure modulating processes over different timescales, and discuss how a better understanding of these modulations could lead to a development of new treatment targeting the clinical impact of seizures.