Computational approaches to rational strain design for industrial biotechnology

The use of computational modelling for redesigning metabolic networks has received much attention over years in industrial biotechnology. Traditional techniques are at most applicable to redesign small networks for the overproduction of biochemicals of interest, and encounter huge challenges for genome-scale networks. In this talk, I am going to explain how to mathematically formulate strain design tasks and how to alleviate computational difficulties to identify good genetic perturbations at genome scale with reasonable computational time cost.