Longitudinal connectivity predicts changes in cognitive function after mild traumatic brain injury

Most mild traumatic brain injury (mTBI) patients show good recovery over the first 12 months after injury. However, a small percentage of patients experiences persistent cognitive deficits. We need to improve our understanding of the brain mechanism influencing the recovery, to be able to design better rehabilitation strategies. Using graph theory and regression analysis, we were able to find changes in connectivity of specific brain regions, that have a strong temporal association with cognitive recovery following mTBI. We hope this will lead to a better understanding of the brain injury mechanism in the future.