Spatial concerns in synthetic biology designs

by Ruud Stoof

16:00 (40 min) in USB G.003

Synthetic biology aims to alter an organism such that it displays a behaviour that is desired.

A challenge in synthetic biology is that even though some correlations with certain genes might be known, achieving desired dynamics in a system organism takes a lot of experimental trail and error. Altering the genetic information in such a way that the resulting dynamics are reliably predictable is stil out of reach for now. SynBio3D is aiming to introduce an extra part in genetic design: the distance between a regulatory Transcription Factor (TF, a protein up or down regulating a target gene) gene and the target gene of that TF. Doing this allows us to explains some findings in previous works and could improve the prediction of the dynamics resulting from a genetic design.