Programmable synthetic RNA origami in vivo: from synthesis to folding

by Alessandro Ceccarelli

16:00 (40 min) in CT 7.01

The DNA origami technology is pushing the boundaries of nano-engineering further everyday. New devices are designed, from biosensors to living computers. Many in vivo applications are arising, although none of them considers the synthesis of origami inside the living cell. Furthermore starting biological materials have often viral origin, and this could cast many doubts concerning the safety of medical applications and, crucially, make its programmability more difficult. Here I document my progress towards creating a programmable, living, universal constructor for RNA-based origami.